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Title   Expression of Cyclin D1 and CDK4 in DMBA - Induced Rat Ovarian Cancer
Publicationinfo   2001 Jan; 033(03): 229-236.
Key_word   Ovary neoplasm , 7,12-dimethylbenzan thracene , Cyclin D1 , Cyclin - dependent kinase 4
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Abstract   Purpose : Ovarian cancer is a common gynecologic malignancy and the leading cause of death in women. It is typically not diagnosed until it has reached the advanced stages. We performed this study to investigate the roles of the proteins related to the G1 cell cycle in ovarian carcinogenesis. Materials and Methods : Immuno his toche mistry and Western blot were used to analyse the expression of cyclin D1 and CDK4 in 7, 12 - dimethylbenzanthracene - induced ovarian cancer in rats. Results : the Cyclin D1 ad CDK4 labelling index was significantly higher in the ovarian cancers than in the normal ovarian surface epithelium of rats. There was no difference among the cancer types. In western blot analyses, the expression of cyclin D1 and CDK4 in the ovarian cancers was higher than in the normal ovarian surface epithelium. A positive correlation was observed between the expressions of the CDK4 and Cyclin D1. Conclusion : The upregulation of cyclin Dland CDK4 that occurs in DMBA - induced rat ovarian carcinogenesis is likely to be associated with tumor progresion. Further studies are needed to investigate the role and function of cyclin D1 and CDK4 in human ovarian cancer. ( Cancer Research and Treatment 2001 ; 33:229 - 235 )
저 자   김기원(Ki Kwon Kim)